NAD+ Explained

What is NAD+

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Nicotinamide Adenine Dinucleotide (NAD) is a naturally occurring coenzyme in our cells that is responsible for cellular energy and nutrition, DNA repair, and DNA transcription.

Mitochondrial Health

Significantly, NAD+ plays a critical role in mitochondrial health, a hallmark of maintaining youth. As we age, our NAD+ levels rapidly decline which contributes to increased fatigue, inflammation, illness, and deteriorating health.

Cellular Energy

NAD+ supports the health of our cells by delivering energy. Studies have found that cells lacking energy show more visible signs of aging such as wrinkles, fine lines, and sagging skin.

About Naderma:

Naderma was developed to change the way youthful-looking skin is achieved. NAD+ nourishes skin cells to deliver a radiant glow without compromising the skin’s natural integrity.

Our skincare products were created alongside research in Nicotinamide Adenine Dinucleotide (NAD), a coenzyme found in all living cells. Naderma offers an innovative approach to rejuvenate and preserve skin health.

The Science Behind NAD+:

A vital source of energy production within the cell, NAD+ supports healthy aging by encouraging biological reactions. As we age our levels of NAD+ decline, making these essential reactions occur less frequently. This can lead to age related disease, including cognitive deterioration, cancer, metabolic disease, arthritis, hypertension, and diabetes. By supplementing NAD+ therapeutically, many of these ailments can be slowed down or reversed.

The reduction of NAD+ into NADH is essential to many cellular functions/maintaining cellular energy. As we age, the balance of catabolic and anabolic reactions within the cells shifts out of balance, creating a deficiency in NAD+. Without sufficient NAD+, the cell cannot conduct the processes it needs to. More than 300 enzymes depend on NAD+ to complete their reactions, including maintenance and repair of DNA, genomic stability, epigenetic regulation, and chromatin remodeling. All these processes are essential for maintaining health and lengthening lifespan.

Various NAD+-supplementing therapies have proven to be effective in extending the length and quality of life. By providing high concentrations of NAD+ to the skin, many visible signs of aging can be erased. From repairing UV damage to diminishing fine lines and wrinkles, NAD+ has been shown to be effective at restoring the youthful glow in your skin.

Why Our Skin Needs NAD+:

  1. Cellular Health:
    Diminishing NAD+ levels have been linked to a variety of age-related ailments and a decline in cellular energy. Within the cell, NAD+ is concentrated in the nucleus, mitochondria, and cytoplasm. Levels of NAD+ decline within the cell as we age, causing a reduction in cellular energy and therefore a reduction in the productivity of the cell and cellular processes.
  2. Anti-aging:
    As we age, our bodies produce less NAD+. A decline in NAD+ causes visible aging, including fatigue, inflammation, deteriorating health, fine lines and wrinkles, sagging skin, and uneven pigmentation. By providing a source of NAD+ topically, the skin is able to repair cell damage and slow down the aging process.
  3. Sirtuins:
    Known as the longevity gene, sirtuins prevent cellular aging by keeping telomeres intact. When telomeres deteriorate, the cell dies. With skin having such a high cellular turnover rate, it is essential that there is a constant source of NAD+ to prevent damage to the DNA and cell death.
  4. UV Damage:
    Overexposure to UV rays causes a decline in ATP, the source of energy in our cells. By including NAD+ in your skincare, we can restore ATP levels in our cells.
  5. Boosts production of collagen, elastin, hyaluronic acid and keratin:
    These components are important in making sure the skin stays strong, elastic, hydrated, and healthy. Without them, the skin appears dull and fine lines and wrinkles become more apparent.
  6. Mitochondrial Health:
    NAD+ plays a critical role in mitochondrial health, a hallmark of maintaining youth. As we age, our NAD+ levels rapidly decline which contributes to increased fatigue, inflammation, illness, and deteriorating health.

Research and Articles:
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About Our Ingredients:

  • Lauryl Lactate, also known as Hydroxy Acid, blocks the release of melanin for a more even skin tone. It hydrates, prevents damage from the sun caused by UBV radiation, reduces the appearance of fine lines and wrinkles, and breaks down lactic acid to help with plumping.
  • Niacinamide improves skin texture and complexion and is essential in cell metabolism and energy production in the cell.
  • Peptides increase collagen and elastin production, build a stronger skin barrier, reduce fine lines and wrinkles by plumping and firming skin, reduce inflammation and even out skin tone.
  • Lysophosphatidic Acid helps skin stay moisturized, enhances elasticity, improves tone and firmness, and repairs your skin barrier.
  • The form of retinol present in Naderma can be used in sensitive areas with little irritation. Retinol is known to increase cell production, unclog pores, exfoliate skin, increase collagen production and reduce the appearance of fine lines and wrinkles.
  • Naderma is formulated with two different types of Vitamin C – lipid and aqueous – which have different rates of penetration. This helps to addresses oxidative stress and provides antioxidant protection. We do not use ascorbic acid, which means that this pH neutral Vitamin C does not cause irritation and does not oxidize.
  • Vitamin E acts as an antioxidant, protects skin from losing moisture, prevents cell damage and softens the skin.
  • Rosehip is a recovery agent. It is an anti-inflammatory, anti-aging, vitamin rich, moisturizing  ingredient  that enhances the results of Naderma’s skincare products.
  • Probiotics are included to help your skin maintain a healthy microbiome.