What is NAD+?
what is NAD+?
NAD+ (Nicotinamide Adenine Dinucleotide) is an organic coenzyme found within our cells that is responsible for cell energy, DNA repair, and DNA transcription. NAD+ functions as an electron carrier, meaning it is used by the cell to “pull” and “carry around” electrons to various compounds to complete biological reactions. Over 300 enzymes depend on NAD+ to complete their biological reactions, including the maintenance and repair of DNA, genomic stability, epigenetic regulation, and chromatin remodeling. Based on medical research backed by the Buck Institute for Research on Aging and UCSF Department of Medicine, the biological reduction of NAD+ into NADH is one of the most essential reactions to maintaining the cell’s energy.
As a vital source of energy within the cell, NAD+ supports healthy aging by encouraging balanced biological reactions. These processes are critical for maintaining health and lengthening lifespan.
why do I need NAD+?
Based on a Harvard Medical School study, our levels of NAD+ decline as we age making essential biological reactions occur less frequently. Studies have also suggested that oxidative injury from decreased levels of NAD+ can accelerate skin aging specifically. Additionally, decreased levels of NAD+ can lead to other age related diseases such as cognitive deterioration, diabetes, metabolic disease, hypertension, and cancer.
As we age, the balance of catabolic vs. anabolic cellular reactions slowly shifts out of balance, creating a deficiency of NAD+. By supplementing NAD+ therapeutically, many of these age-related ailments can be slowed down or even reversed.
does NAD+ impact skin?
NAD+ supplementation therapies have proven to be effective in extending the length and the quality of life. A 2019 research study found that “maintaining adequate NAD+ level is essential in skin cancer patients and individuals at risk of exposure to genotoxic agents.” By providing high concentrations of NAD+ to the skin, many visible signs of aging can be erased.
From repairing UV damage to diminishing fine lines and wrinkles, NAD+ has shown to be effective at restoring the youthful glow in your skin.
NAD+ levels in our body are critical to fighting oxidative stress and slowing down the process of aging skin. As we age naturally from day to day activities, our bodies produce less NAD+ over time. That natural decline in NAD+ levels causes visible signs of aging such as fine lines and wrinkles, inflammation, sagging skin, uneven pigmentation, fatigue and deteriorating health. By providing a source of NAD+ topically, the skin is able to repair cell damage and slow down the aging process.
Studies prove “the effects of NAD+ on increasing life span have been linked with the activation of Sirtuin 1, Sirtuin 2, etc.” Widely known as the longevity gene, Sirtuins are responsible for keeping telomeres in tact. Our telomeres, which keep the ends of our DNA chromosomes from unraveling, deteriorate over time thus affecting DNA replication. NAD+ plays a key role in regulating metabolism and circadian rhythm through Sirtuins.” It is essential that there is a constant source of NAD+ to support longevity in our bodies and to keep our DNA chromosomes strong.
NAD+ plays a critical role in mitochondrial health, a hallmark of maintaining youth. During youth, mitochondria readily generates NAD+ inside of the cell. Over time, weakened mitochondria struggles to maintain NAD+ levels, creating an NAD+ deficiency. Rapidly declining NAD+ levels contribute to increased fatigue, inflammation, illness, and deteriorating health.
NAD+ has been found to promote the production of peptides that work together to form stronger, more elastic, moisturized and hydrated-looking stratum corneum, the outermost layer of skin. Research on the relationship between skin and collagen supplementation concluded that collagen peptides have the power to either “reduce[s] or delay[s] skin aging“. Furthermore, the science suggested that topical use of NAD+ improved the appearance of wrinkles and elasticity in the skin.
Ultraviolet (UV) radiation damages and ages the skin by altering DNA chromosomes. UV ray exposure can cause cellular aging, death of the cell and skin cancer. UV damage also causes inflammation, immune changes and visible skin aging. Appropriate NAD+ levels in our body have the power to counteract these negative changes.
Diminishing NAD+ levels have been linked to a variety of age-related ailments and a decline in cellular energy. Within the cell, NAD+ is concentrated in the nucleus, mitochondria, and cytoplasm. Levels of NAD+ decline as we age, causing a reduction in cellular energy; therefore, a reduction in the productivity of the cell and cellular processes.